Bio-Techne Company right now introduced that Superior Cell Diagnostics (ACD), a Bio-Techne spatial biology model, has set a brand new customary with the event of a next-generation, protease-free RNAscope spatial multiomics workflow.
Optimized for same-slide detection of protein and RNA biomarkers with unparalleled sensitivity and tissue morphology, the newly developed RNAscope spatial multiomics workflow is appropriate with each handbook and automatic assays. ACD’s novel protease-free RNAscope workflow is integrated in Bio-Techne’s just lately introduced best-in-class multiomics software on Lunaphore’s COMET platform.
Simultaneous imaging of each RNA and protein biomarkers on the identical tissue part will present an unprecedented single-cell view of illness pathology and therapeutic response. ACD’s new innovation marks a big enchancment over present spatial applied sciences that are designed for the detection of both RNA or protein, not each, and usually result in the degradation of the alternate biomarker sort.
By eliminating the necessity for proteases typically utilized in RNA detection, this superior workflow preserves protein and RNA integrity and conserves tissue morphology. With this development, subcellular gene expression and multiomic adjustments could be simply quantified and picture and information evaluation are additional simplified.
We’re proud to realize one other milestone in our spatial multiomics technique with the event of a novel, protease-free RNAscope workflow. We’ve got been impressed by the overwhelmingly optimistic response obtained from clients who’ve examined this new workflow with our present on-market RNAscope assays, and we look ahead to providing this new functionality throughout our RNAscope portfolio this yr.”
Kim Kelderman, Chief Working Officer, Bio-Techne
Bio-Techne’s ACD model is a pioneer in spatial biology, delivering industry-leading single-molecule sensitivity and unmatched specificity with its patented RNAscope ISH know-how for over 10 years. With over 9,500 peer reviewed publications and over 50,000 distinctive probes bought, RNAscope know-how has enabled the spatial detection of the widest vary of RNA subtypes within the {industry} from analysis to scientific purposes.
Knowledge shall be showcased in a sequence of actions on the Lunaphore Suite, Curacao 4 on the Advances in Genome Biology and Know-how (AGBT) 2024 Basic Assembly in Orlando Florida on February 5-8. Further information demonstrating technical advances within the codetection of RNA with each proteins and protein-protein interactions utilizing RNAscope shall be introduced at AGBT by ACD scientist Ge-Ah Kim, Ph.D. on Feb 7 at poster #633 titled “Single-slide, in situ multiomic imaging of mRNA, protein and protein-protein interactions within the tumor-immune microenvironment of bladder most cancers sufferers.”
